Search results for "VAGINAL CORNIFICATION"

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Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study

2003

International audience; The objective of this study was to compare the estrogenicity of xenoestrogens found in food wrap packaging and phytoestrogen flavonoids. Uterotrophic and vaginal cornification assays were performed on immature and ovariectomized rats. Genistein, bisphenol F, and octylphenol were identified as estrogenic only in immature rats. Using vaginal cornification as a more specific estrogenic parameter, all tested compounds except tangeretin were active in immature rats. While apigenin and kaempferol appeared to have low estrogenic activity, they potentialized the uterotrophic effect of 17β-estradiol in immature rats. These data showed that (i) phytoestrogens like genistein ca…

Genistein010501 environmental sciencesToxicology01 natural scienceschemistry.chemical_compound[SDV.IDA]Life Sciences [q-bio]/Food engineering0303 health sciencesIMMATURE RATSEstradiolMolecular Structurefood and beveragesOrgan SizePHYTOESTROGENS[SDV.IDA] Life Sciences [q-bio]/Food engineeringVAGINAL CORNIFICATIONVaginaApigeninToxicityOvariectomized ratFemalehormones hormone substitutes and hormone antagonistsmedicine.medical_specialtymedicine.drug_class[SPI.GPROC] Engineering Sciences [physics]/Chemical and Process EngineeringOvariectomyXENOESTROGENSBiologySensitivity and Specificity03 medical and health sciencesPredictive Value of TestsIn vivoInternal medicinemedicineAnimals[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process EngineeringEstrogens Non-SteroidalRats Wistar030304 developmental biology0105 earth and related environmental sciencesFlavonoidsDose-Response Relationship DrugOVARIECTOMIZED RATSUterusEstrogensUTEROTROPHIC ASSAYIsoflavonesRatsEndocrinologychemistryEstrogenPhytoestrogensPlant PreparationsKaempferol
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